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In addition, the indole core is substituted at R3 by using a carbonyl group which can be also bonded to a napthalene moeity. Napthalene is really a bicyclic construction of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it being a ketone. JWH-018 can be an analog of THJ-018, during which the core indazole structure is substitut